Association of early surgery and post-operative complications in patients with infective endocarditis

Abstract Funding Acknowledgements Type of funding sources: None. Background Infective endocarditis (IE) is a disease associated with high risk morbidity and mortality. Recent literature suggests that surgery during index hospitalization may be performed safely without increased However, the post-operative complications remains unclear. Purpose The purpose this meta-analysis to assess association early as compared delayed in patients IE. Methods We search for studies reporting an between study endpoints. primary endpoint was neurological complications. secondary endpoints were systemic embolic events, recurrence IE, need reoperation. Early defined within 14 days admission. included following databases: Ovid MEDLINE, EMBASE, Web Science, Google Scholar. not restricted time or publication status. Results A total 11 1857 participants (634 vs 1223 surgery) included. mean duration follow-up 39 months (ranging 6 66 months). (OR 1.01, 95% CI 0.55, 1.85; P=0.98). Heterogeneity low: Chi2 = 2.93, I2 0%. reoperation 0.98, 0.6, 1.61; p=0.94; OR 1.66, 0.83, 3.33; p=0.15; 2.18, 0.41, 11.69; p=0.36). Conclusions initial surgery.